KIN408 Study Guide - Midterm Guide: Atrioventricular Node, Pacemaker Potential, Cardiac Muscle Cell

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Cardiac cells are connected by low-resistance gap junctions forms the functional syncytium: at depolarization, depolarizing currents pass through gap junctions & depolarize adjacent cells, this result in cell to cell propagation of ap. Intercalated discs: form cell-cell linkages via different proteins within the discs: aids force of transmission in lv and rv, gap junctions: creates an electrochemical linkage b/w adjacent cells. Formed by ion channels: gap junctions are found within intercalated discs. Triggered by depolarization of adjacent cells via gap junctions. Pacemaker ap in sa & av nodal cells. Electrical conduction system: atria and ventricles are electrically isolated by connective tissue (non-conducting) except at the av node, av node creates a controlled access point of depolarization to make sure the pumping is coordinated. 4 (cid:9: depolarization at sa node spread to non-pacemaker cells via gap junctions. Sympathetic stimulation, muscarinic receptor antagonist: - adrenoceptor agonists, circulating catecholamines/ hyperthermia. Factors decreasing sa node firing: parasympathetic stimulation, muscarinic receptor agonists, - blockers.

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