MICB 202 Study Guide - Final Guide: Internal Ribosome Entry Site, Eukaryotic Small Ribosomal Subunit (40S), Cd155
Document Summary
Describe the structure of the poliovirus capsid and genome icosahedron shape. Contains single piece of (+) sense rna. Capsid has 20 triangular faces made up of 60 copies of its 4 structural proteins. Each triangular face made of 3 subunits (each made of 1 copy of 3 structural proteins. Describe the replication process of the poliovirus including: The host cell receptor used and the cell types expressing that receptor. Cd155 (normal cellular proteins) receptor on host (virus receptor) Member of the ig gene superfamily (cd4, cd8, mhc i & ii) cell surface molecule expressed on monocytes, macrophages, thymocytes and cns neurons also referred to as pvr (poliovirus receptor) How the virus genome enters the host cell. Vp1 (poliovirus) binds to cd155 molecule (susceptible cell) conformational change in n-terminus vp1 can insert into lipid bilayer of host cell forms a pore allows viral rna to leave the capsid and enter cytoplasm.
