MICB 202 Study Guide - Inactivated Vaccine, Attenuated Vaccine, Reverse Transcriptase
Document Summary
Mrna protein (ds)dna transcription translation nucleotides nucleic acids (rna and dna) amino acids proteins (specific functions) Viruses vs cells: simple structure, genetic information is encoded by dna or rna, living cell help replicate. Obligate intracellular parasite depend on living host cell for replication. Limited genome size genes allow for: Any required function cannot adapt from host cell. Non-symmetric protein molecules identical equilateral triangular structures. Some mature virion will have virus-encoded enzymes within capsid. Host cell does not provide suitable enzyme. Virus cannot utilize cellular form of enzyme. Cause of pathological effects toxic effects of viral gene products (proteins) on host cell metabolism. Host immune system reacts/destroys infected cells expressing viral genes. Structural/functional interactions w/ virus gene material modifies host genes. Virus replication cycle may destroy host cell. Enzymes: dna ligase, reverse transcriptase, rna polymerases, rnase h. Virus use rna or ss dna as genome. Virus replication cycle entire process from attachment to release from cell.
