NURS 310 Study Guide - Final Guide: Prostaglandin, Factor X, Ticlopidine
Document Summary
Hemostasis = process in which clotting factors are involved in the slowing/stopping of blood flow. It"s a mechanism that protects the body from both external and internal injury. Vessel injury leads to spasm and constriction, restricting blood flow to injury site . Platelets have high affinity for injury site, and stick to each other and to injured spot. Adp, thrombin and thromboxane a2 assist in aggregation, and adhesion is aided by platelet receptor sites and von willenbrand"s factor. As the sticky platelets finish their job, they break down, and release substances to attract more platelets to the area. Blood flow is even more slowed down, which is what causes coagulation and the coagulation cascade. There are two pathways for the coagulation cascade (both lead to fibrin clot formation): At this phase, a coagulation cascade occurs, where fibrin threads begin. This stitch fortifies the blood constituents so they form a clot . Intrinsic pathway = activated in response to injury.
