HSS 1100 Study Guide - Midterm Guide: Serology, Leptospira, Syphilis

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 1100
• Professor: Franco Pagotto

Document Summary

Ha(cid:448)e (cid:449)a(cid:454)(cid:455) (cid:272)oats, ri(cid:272)h i(cid:374) lipids: (cid:272)a(cid:374)"t (cid:271)e gra(cid:373)-stained. Primary tb: (cid:271)a(cid:272)teria i(cid:374)haled (cid:373)ultipl(cid:455) i(cid:374) al(cid:448)eoli sur(cid:448)i(cid:448)e i(cid:374)side macrophages. Post-primary tb: late reactivation of silent lesions in tuberculin + people (have some immunity); chronic. 1) tuberculoid leprosy: erythematous plaques, peripheral nerve damage, nerves enlarge (low infectivity, few bacilli present) 2) lepromatous leprosy: disfigures, limb loss, high infectivity, dangerous (high infectivity) Diagnosed also via microscopy (fluorescent or ziehl dyes) or cultures. Aids patients are high risk for post-primary tb. Gives doubtful tuberculin test (cannot distinguish from tb) Gra(cid:373) (cid:374)egati(cid:448)e (cid:894)(cid:271)ut does(cid:374)"t stai(cid:374) as such b/c strange cell wall) Serology to diagnose: non-specific indirect elisa: use cardiolipin as antigen (similar to treponema, specific, treponemal test. 2) 2ary: rash (general or local), mucous lesions. 4) latent: life carrier w/o symptoms; passed via birth. Antibiotic (takes long time to treat deep tissue infection) Severity depends on amount of pathogen, state of host, virulence of strain.