BIO200H5 Study Guide - Midterm Guide: Drug Design, High-Throughput Screening, Chronic Toxicity
Document Summary
Pharmacology is the interdisciplinary study of substances that interact with living systems through chemical processes, especially by binding to regulatory proteins and inhibiting or activating normal processes. What are two important things to remember about all drugs: all drugs can be toxic. (herbs=more impure, all health enhancing supplements should have the same efficacy as drugs and medical treatments. Something that recruits or interacts with a drug/ligand with measurable affinity for a period of time. A drug target must also have the right size, the right charge, the right shape, and the right atomic composition. Drugs must also be administered to the body without being completely destroyed and must be eliminated after a certain time. Some examples of targets are nucleic acids (rna) or proteins (cytoplasmic proteins, receptors, enzymes. The central dogma of cell biology is that dna is transcribed into mrna which is translated into proteins. List and explain some different types of proteins pertaining to pharamacology. (4)
