BIO207H5 Study Guide - Midterm Guide: Retinitis Pigmentosa, Muscular Dystrophy, Amelogenesis
Document Summary
Reciprocal cross same genotypes are crossed but sexes of parents are reversed. 1 genes act in random to produce phenotype (all of. Test cross unknown genotypes cross with pure-breeding (homozygous recessive) 2 dominant alleles or either genes produce wild type phenotype. Binomial prob (p+q)n, n = # of successive events. 4 rec alleles at one gene mask/ reduce expression of alleles at interacting locus (aa) 5 dom allele of one gene mask/ reduce expression of alleles at 2nd gene (a) 6 dom allele of one gene suppresses expression of dom allele of 2nd. Null (amorphic) no functional gene product, often lethal in homoz. Neomorphic novel gene activity (differ than wild. Leaky (hypermorphic) function retained but at lower level than wild type. Hypermorphic more gene activity per allele than wild type (same product as wild type) type) Dom negative change in one component of multimeric protein making it dys. Auto dominant affected individual has affected parent.
