IMM250H1 Study Guide - Antigen Presentation, Signal Transduction, Cell Signaling

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3 Feb 2013
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T-cell Receptor Gene Diversity
T Cell Receptor (TCR)
Ig superfamily member receptor
Restricted to CD4+ (helper) and CD8+ (killer) T lymphocytes
Always membrane bound
Antigen binding domain also contains 2 CDRs
CDR3 is the main antigen contact
CDR1 and CDR2 contact MHC receptors on another cell
MHC restriction of T cell recognition
T Cell receptor diversity
Generated through the same mechanism as Ig diversity
Involves RAG-1, RAG-2, RSS, all the same enzymes & P- and N- nucleotide addition
TCR α and β chain domains ≈ light chain and heavy chain of Ig
TCR α V J C
TCR β V D J C [ slightly more variable than α]
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