Study Guides (247,995)
Canada (121,213)
BIOC 299 (5)

BIOC 299 Midterm: UVic Bioc 299 Midterm 2 Notes

2 Pages
Unlock Document

BIOC 299
Briant Douglas

Chapter 16- Glycolysis • Enzymatic Steps o 10 successive reactions that occur in the cytoplasm + o Glycolysis net +eaction: glucose + 2 ADP + 2 NAD + 2 P  2 piruvate + 2 ATP + 2 NADH + 2 H + 2 H O 2 o Three stages of glycolysis: ▪ 1. Trap and destabilize glucose • Kinases are enzymes that catalyze the transfer of a phosphoryl group from ATP to an acceptor 2+ • Hexokinase, as well as other kinases, require Mg for activity • Two lobes of hexokinase move together when glucose is bound (induced fit) • Substrate-induced cleft closing is a general feature of kinases • Next step is isomerization of glucose 6-phosphate to fructose 6-phosphate • The isomerization of glucose 6-phosphate to fructose 6-phosphate is a conversion of an aldose to a ketose, reaction is catalyzed by phosphoglucose isomerase. • Isomerization important because later only 3 carbon molecules are metabolized • Fructose 6-phosphate is phosphorylated by ATP to fructose 1,6- biphosphate • Phosphorylation is one of the major regulatory points in glycolysis, big drop in free energy and energetically favorable • This irreversible reaction is catalyzed by phosphofructokinase (PFK) • Phosphofructokinase is an allosteric enzyme that is the key regulatory enzyme for glycolysis • ▪ 2. 6 to 3 C molecule conversion • The fructose 1,6-bisphosphate is split into two triose phosphates, glyceraldehyde 3-phosphate (GAP), ad dihydrozyacetone phosphate (DHAP) • This is catalyzed by aldolase • The triose phosphate isomerase catalyzes the isomerization of three- carbon phosphorylated suga
More Less

Related notes for BIOC 299

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.