BIOC 300B Study Guide - Final Guide: Transferase, Methionine, Release Factor
Document Summary
Link amino acid to trna therefore implementing the genetic code. Trna serves as adapter molecule that binds to as speci c codon and brings with it an. 4-letter alphabet of nucleic acids translated into 20 amino acids. Depends on both protein and nucleic acid factors. Molecules that play roles in protein synthesis are trna, mrna, ribosomes and many proteins. Link between amino acids and nucleic acids are amioacyl-trna synthetases. Proteins are synthesized in the 5"-->3" direction (howard dintzis experiment) Fidelity of protein synthesis requires accurate recognition of three-base codons on mrna. Amino acid can not itself recognize the codon. Amino acid is attached to a trna that can recognize the codon amino acid for chain. About half ribonucleotides are base paired to form db helices. 3" end of activated amino acid has aa attached to oh group of adenosine resiude of acceptor stem. Anticodon present in loop in middle of molecule.