Biology 3593B Study Guide - Quiz Guide: Haematopoiesis, Yolk Sac, Immunoglobulin G
Document Summary
The early life immune system: cell movement -gastrulation. Development foetus: highly protected environment: hence balance strongly in favour of tolerance, not non-functional, just highly regulated, prevent damaging and energetically costly inflammation, note energy requirements development: protein / organelle synthesis. Specific challenge minimise energy expenditure focus rgwoth / development. Primitive macrophages" identified from 21st day gestation: aorta-gonad-mesonephros (agm, not found b and nk cells, but should be able to make them, fetal liver, bone marrow, dcs capable lymph migration / antigen presentation, definitive haemato. Previously thought nothing crossed placenta but now know bidirectional: see slides for maternal tolerance evidence -lasted into aduldhood better. 2019 li showed presence memory t cells produce pro-inflammatory: potentially other ag crossing. Skin primed for defence: waxy coating venix caseosa: antimicrobial proteins: lysozyme, defensins, ubiquitin, also rely innate environment. Different properties: neonates , reduced net generation ability, reduced extracvasation, depleted l-arginine reduced ability to make tnf, tregs abundant.
