Biology 3593B Study Guide - Quiz Guide: Angiotensin Ii Receptor Type 1, Echocardiography, Angiotensin
Document Summary
In established heart failure, sympatho-excitation is linked to a dysregulation of the no- Gaba tonic inhibition, and an increase in an angii and glu-related excitation. Preliminary evidence suggests that in the initial stages of hf, sympatho-excitation is not accompanied by down-regulation no-gaba inhibition, but there is an upregulation of ros production. The hypothesis is that in early-stage heart failure, increased ros production up-regulates the excitatory actions of angii and glutamate without altering the no-gaba-ergic tonic inhibitory mechanism. Hypothesis: increase sna in hf is mediated by a decrease in no and an increase in ros within the. Increased ros riggers initial excitation through the activation of at1r, leading to an increase in. It is seen that the fractional shortening percentage is significantly decreased at day 21 in. Mi, rsna has doubled in the mi rat but is unchanged in sham. Fra-like expression in the pvn is increased three weeks post-mi.
