BIOL 2020 Study Guide - Final Guide: Dihydrolipoamide Dehydrogenase, Pyruvate Dehydrogenase Complex, Flavin Adenine Dinucleotide

• School: York University
• Department: Biology
• Course: BIOL 2020
• Professor: Emanuel Rosonina

Document Summary

Consumes 1 atp (irreversible: 2; g6p ( phosphoglucose isomerase)-> f6p reversible, 3: f6p ( phosphofructokinase-1)-> : f-1,6-bip. Regulation: f6p ( pfk2)-> : f-2,6-bip -> activates pfk 1 and rest of glycolysis. Insulin + phosphoprotein phosphatase -> activate pfk 2 and inhibit reverse step (fbp-ase 2: glucagon + pka -> inactive pfk 2, 4: f-1,6-bip (aldolase)-> g3p + dhap. Dihydroxyacetone p reversible: 5: dhap (triose phosphate isomerase)- > g3p reversible stage 2: 2 g3p -> 2 pyruvate + 4 atp + 2 nadh + 2h2o: 6: g3p ( g3p dehydrogenase)-> g-1,3-bip + nadh, 7: g-1,3-bip ( phosphoglycerate kinase)-> glycerate-3p. + atp reversible reversible: 8: glycerate-3p ( phosphoglycerate mutase)-> glycerate-2p reversible dg > 0, but consumed energy is small and driven by rapid conversion of g2p in next step, 9: glycerate-2p (enolase)-> pep + h2o. Phosphoenolpyruvate reversible: 10: pep (pyruvate kinase)-> pyruvate + atp irreversible, net: glucose -> 2 pyruvate + 2atp + 2nadh + 2h2o.