BIOL-242 Study Guide - Quiz Guide: Cystic Fibrosis, Paracellular Transport, Fluid Compartments
11 Jun 2020
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Chapter 22 & 26 | quiz study guide. Describe cystic fibrosis (cause, mechanism of action of cftr). Cystic fibrosis is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over. In people with cf, mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene cause the cftr protein to become dysfunctional. time. Cl- secretion by intestinal and colonic crypt cells. Chloride enters cells by indirect active transport and leaves the apical side through a cftr channel. Sodium and water follow passively by the paracellular pathway. Produce a mucus that is very dry, making it difficult to expel it. Bacteria and virus can attach easily to that mucus and stay in the body for extended periods of time. In cystic fibrosis, na+, k+, and cl- enter by cotransport. Negative cl- in lumen attracts na+ by paracellular pathway. Acid-base balance. ph affects all functional proteins and biochemical reactions.
