PB HLTH 162A Study Guide - Final Guide: Transmissible Spongiform Encephalopathy, Ribosome-Binding Site, Polio Vaccine
5 Jan 2020
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Humans are often principle host (no animal reservoir), transmission involves human to human transmission (direct or indirect) Defenses: stomach acid, iga (antibodies secreted on mucosal sites), phagocytic cells, microbiome. Symptoms: diarrhea, nausea, vomiting, fever / low inoculum needed! Polio vaccine: opv (live attenuated) grow @low temp. Can"t eradicate polio b/c opv cheaper, easier to admin, stops. hatched larvae enter circulation & migrate to lungs (human) Larvae coughed up & swallowed > si, where mature (human) Public health importance: identify source, procedural errors in food processing, intervene to protect public (consequences: defamation, loss of public trust, brand reputation, lawsuits, $ loss) Resistant to usual disinfection (need 700 degrees, formaldehyde, or sb soln) Mutated human or animal gene = abnormal prion convert normal prion protein to abnormal (end/do not replicate) Transmitted from one human/animal to another (genetic component of human susceptibility) (ie- alpha > beta sheet / protein used for nerve cell function > protein counteracts)
