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[CAS BI 525] - Midterm Exam Guide - Ultimate 58 pages long Study Guide!


Department
Biology
Course Code
CAS BI 525
Professor
Lucia Pastorino
Study Guide
Midterm

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BU
CAS BI 525
MIDTERM EXAM
STUDY GUIDE

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7 September, 2016
NE/BI525: Lecture 1 (Part 3)
1. Parkinson’s Disease and Diagnosis
a. L-dopa dopamine
b. When symptoms occur 60-80% of dopaminergic neurons have died
c. PET
c.i. Administer radioactive L-dopa: which can help identify healthy dopamine
neurons
c.ii. In PD, decreased signal (less healthy dopamine neurons)
http://www.parkinson.org
c.iii. L-dopa treatment intervention: leads to increased dopamine, rescue
dopaminergic signaling (how does this happen)
c.iv. 18F – Fluorodopa – How advanced the pathology is
Decrease in signaling as disease progresses
c.v. 18F – Fluorodeoxyglucose uptake during PD is decreased than in normal brain
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7 September, 2016
FDG any neuron
2. Huntington’s Disease and Diagnosis
a. MRI Analysis
a.i. Cortex, Cerebellum & Nuclei degenerate
3. Creutzfeldt-Jacob Disease (Mad cow disease, BSE or Prion Disease)
a. Marked brain shrinkage and deterioration occurs rapidly
b. Spongiform pathology characteristic of disease (spongosis)  massive atrophy
c. TSE Family of disease
d. Cognitive/Behavioral Tests
e. MRI – loss of cortical structures
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