BIOS 15115 Study Guide - Final Guide: Sukhoi Su-2, Imatinib, Platelet-Derived Growth Factor Receptor
7 Sep 2016
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Oncogene: a gene that, when mutated, causes a cell to proliferate out of control. Tumor suppressor genes: a gene that, when mutated, can no longer stop over proliferation. Retinoblastoma: rare tumor of the retina, affects 1/20,000 children. Two types of retinoblastoma: familial: inherits one mutant rb (retinal blastoma gene) allele and then acquires a 2nd mutation, sporadic: acquires 2 mutations (one in both copies) randomly. This lead to the idea of a tumor suppressor gene. Some of the hybrids were transformed, but, more often than not, they were not: loss of genes equal in importance to gain of active oncogenes. Rb protein: 105 kda phosphoprotein that can complex with oncoproteins (eia, E7, large t antigen etc. ) and disable their functions: lost or inactive in retinal blastomas. Eia, e7, and large t antigen prevent e2f from binding to rb: e2f is supposed to bind to rb.
