ORB 141 Study Guide - Midterm Guide: Gut Flora, Gper, Estradiol
21 Dec 2020
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Female sex hormone levels influence microbiota composition in many sites of the body, especially mouth and gut. Oral and gut microbiota have been shown to influence many diseases, such as osteoporosis, weight gain and lipid deposition, breast cancer and periodontitis. *both men and women have both male and female hormones it"s the predominance that matter with respect to physical appearance and reproductive fxn. Take away from this is that all of these hormones come from cholesterol. Also aromatase converts testosterone to estradiol and 5alpha reductase converts testosterone to dht. Sex steroids produced by ovaries, testis, adrenal gland. Estrogens bind to 2 nuclear rs: er alpha, er beta (classical pathways) mediate genomic (reproductive) actions. Or binds to a pm gpcr (gper) that plays central role in regulating vascular tone, cell growth, and lipid and glucose homeostasis. Progesterone (p) binds to intracellular progesterone-r (prepares body for pregnancy) Testosterone: in many cases, it fxns as a pro-hormone bc.
