PCB 4594 Study Guide - Comprehensive Final Exam Guide - Messenger Rna, Mesoderm, Gene
Document Summary
Name 4 model organisms commonly used in regeneration research. Key protein in patterning that encodes proximal/distal values in regenerating limbs. Family of proteins found in salamanders that also appear to be involved in regeneration. Most cells in culture can"t divide indefinitely but will age and no longer divide after a tissue-specific limit. Replication (# of cell divisions) & to stress. What are the 2 cell autonomous processes that influence development of cellular aging? p16-ink4a & arf. This mechanism evolved in older cells to prevent cancer. High levels of these proteins contribute to cellular aging and the hayflick limit. When telomeres become too short, cell can"t divide. Insulin signaling was first discovered in which animal model: elegans. Gain of function: hypermorphic mutant, neomorphic mutant. Gain an additional function that it didn"t have before. Unbiased genetic screen for mutations that disrupt a specific biological process. You are creating mutations and hope that it changes something.
