AS.020.305 Midterm: cell bio final study sheet (dragged) 4
Document Summary
The resulting activation of g1/s-cdk then drives progression to the start checkpoint. G1/s-cdks release a wave of s-cdk activity, which starts chromosome duplication in s phase and also contributes to some early events of mitosis. M-cdk activation then triggers progression through the g2/m checkpoint and the events of early mitosis, leading to the alignment of sister chromatids at the equator of the mitotic spindle. Finally, the apc/c, together with its activator cdc20, triggers the destruction of securing and cyclins at the metaphase-to-anaphase transition, thereby unleashing sister-chromatid segregation and the completion of mitosis. *s*phase: a cell must solve two problems when initiating and completing dna replication. First, replication must occur with extreme accuracy to minimize the risk of mutations in the next cell generation. Second, every nucleotide in the genome must be copied once, and only once, to prevent the damaging effects of gene amplification.
