MATH 41045 Study Guide - Midterm Guide: Genetic Disorder, Mendelian Inheritance, Centromere
30 Oct 2019
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Integrated Cell Division/Cystic Fibrosis Genetics Case Study
This lab has been adapted from the original case study, Sometimes It IS All in the Genes by Anne Galbraith
and David Howard, Department of Biology, University of Wisconsin--LaCrosse. Copyright held by the
National Center for Case Study Teaching in Science, University at Buffalo, State University of New York, all
rights reserved. Used with permission.
Objectives:
• Students will be able to demonstrate their understanding of the steps in
meiosis and the random assortment of alleles in the resulting gametes.
• Students will be able to apply their knowledge of Mendelian genetics to
calculate the probabilities of inheriting specific traits and passing them on
to offspring.
• Students will be able to demonstrate their understanding of the
relationship between meiosis and the probability of offspring inheriting
specific traits.
• Students will be able to correctly use relevant terminology.
• Students will be able to explain the relationship between genotype (DNA,
allele) and phenotype (protein, disorder).
Background:
Nancy, a visibly pregnant woman, visits her OB/GYN, Dr. Kwin, for a routine
prenatal checkup involving blood work. During her office visit, Dr. Kwin asks
Nancy whether she would consent to participating in a genetics study being
conducted at the hospital. The research team is studying the frequency of the
gene for the genetic disorder, cystic fibrosis (CF). Dr. Kwin goes on to explain
that the cystic fibrosis is a recessive disorder, requiring two copies of the
recessive allele for an individual to exhibit symptoms of the disorder. Dr. Kwin
provides Nancy with some further information regarding the severity of the
disease, the proper consent forms for participating in the study and advises her
to carefully consider whether or not she would want to have her results reported
to her.
Pre-lab assignment:
1.Complete the table comparing mitosis and meiosis
Mitosis
Meiosis
Where does it occur?
Function?
Number of cell
divisions?
Number of cells
produced?
Diploid or haploid?
New cells genetically
identical or unique?
Prelab questions continue on the next page!
2. Define the following terms:
a. sister chromatid
b. homologous chromosome
c. chromatin
d. centromere
3. Review the stages of meiosis in the textbook then draw a sketch of the stages
of meiosis in an organism with 4 chromosomes (2n=4). One pair of
chromosomes (Chromosome 1) is MUCH smaller than the other pair of
chromosomes (Chromosome 2). Use different colors to denote the maternally-
inherited and paternally-inherited chromosomes (e.g. maternal is red, paternal is
blue). Don’t forget what happens during recombination. HINT: there is a VERY
similar picture of this in your textbook!
Sketch
