BIOL 2051 : Chapter 24 Notes (got 96%)
Document Summary
Self proteins on surface of cells: bind to antigen, antigen/mhc complex is recognized by t cell receptor cells, class i mhc proteins on surface of all nucleated cells; presents intracellular antigens to tc, class ii mhc proteins on surface of antigen presenting cells; present extracellular antigen, t cells become activated when antigen/mhc binds to t cell receptor (*fig 24. 20*) to th cells. Hinge region allows each fragment to bind antigen independently. Igm : second most abundant ig, 1 st class of antibody made, aggregate of 5 molecules attached by disulfide bonds and j chain protein, can bind up to 10 antigens, mu in response to infection heavy chains. Immune response diseases: hypersensitivities inapproptiate immune response resulting in host damage, superantigens pathogen proteins that cause widespread stimulation of immune cells; result massive inflammatory response, tissue damage, damage is not from the protein but from the over reaction of the immune response.
