BIOL 3090 Study Guide - Final Guide: Retinoic Acid Receptor, Dna-Binding Domain, Histone Deacetylase
Document Summary
Nuclear receptors are a family of tf that respond to lipid soluble hormones that cross the membrane, they have 3 functional regions, dna binding (cterminal), hormon binding domain (c- terminal), and hormon dependent activator domiain (n terminal). They bind hormones, move to nucleus and activate transcription. Can act as hats or hdac depending on whether they have a ligand or not, Heterodimeric nuclear recepros, found in nucleus only, when bound to dna could be acting as repressors (if not bound with ligand) by being a hdat. or an activator (if bound by ligand, by becoming a hat. Momodimeric nr, found in both nu and cytoplasm, requires a ligand before travling to nucleas. if no ligand bound it has an inhibitor that inhibits it from traveling to nucleus to act as activator. Rna pol iii= t rna 5srna other small rna genes. Both are considered to transcribe transcriptional control elements both do not require atp hydrolysis to initiatie transcription.
