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Final Unit 3 Review (Got A+ on the test)

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Louisiana State University
Biological Sciences
BIOL 3090

Final UNIT 3Linker scanning mutations Fig 721 what are we doing hereWhy are the linkers 10 bps in length SWISNF is a chromatin remodelerWhat does it do and how is it different from HATS required at some promoters for activationswisnf subunitshave homology for helicase facilitate binding of transcription factorstransiently dissociating the dna from nucleosomes free it up for tf activity does not necessarly have to be acelytated chromatin can work on core histone or the wrapped dna itselfrequires atpcan be working hand in hand with hats histone acetyltransferaseSWI5 recruits SWIsNF Chromosme Remodeling complex opens up the chromatinhats come in acylytate the histone core further open promoter proximal region another activator SBF binds PPR a mediator binds SBF and a transcription factor binds the mediator which brings this TF to the promotor allowing transcriptionNuclear receptors Figs 741 742 743 744How can the retinoic acid receptor act both as a HAT and as a HDAC Nuclear receptors are a family of TF that respond to lipid soluble hormones that cross the membrane they have 3 functional regions DNA binding Cterminal hormon binding domain Cterminal and hormon dependent activator domiain N terminalThey bind hormones move to nucleus and activate transcriptionCan recognize inverted repeats Can act as HATS or HDAC depending on whether they have a ligand or notHeterodimeric nuclear recepros found in nucleus only when bound to dna could be acting as repressors if not bound with ligand by being a HDAT or an activator if bound by ligand by becoming a HATMomodimeric nr found in both nu and cytoplasm requires a ligand before travling to nucleas if no ligand bound it has an inhibitor that inhibits it from traveling to nucleus to act as activatorRNA POL IPre rRNARNA POL IIIt RNA 5sRNA other small rna genesBoth are considered to transcribe transcriptional control elementsboth do not require atp hydrolysis to initiatie transcriptionRNA II requires atp
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