BIOL 4160 : Bio 4160 Test 2
Document Summary
Ip3, dag, and ca2+ are all secondary messengers in g-protein coupled receptor transduction pathways: calcium is the most powerful secondary messenger that we know of. Ip3 (inositol triphosphate) and dag (triacylglycerol) are both lipid signaling molecules: this is known as the ip3 pathway, dag activates protein kinase c, which phosphorylated transcription factors and alters gene expression. Ip3 binds to its receptor on the endoplasmic reticulum, which acts as a ca2+ channel and released stored ca2+ into the cytosol. This ca2+ release, through a poorly-understood mechanism, opens a class of plasma membrane ion channels called transient receptor potential channels and allows external ca2+ to enter the cell and replenish depleted ca2+ stores in the er. 2: functional classes of neurons, afferent neurons: Interneurons: found entirely within the cns, responsible for: If neural cells get lost during development, they don"t become part of the functioning brain, damage results. Induce capillaries of brain to undergo changes that aid in establishment of blood-brain barrier.
