CHE 211 Study Guide - Final Guide: Valine, Storage Protein, Peptide

Which of the following statements about protein-ligand binding is correct? The fundamental cause of sickle-cell disease is a change in the structure of: 70. The Ka is equal to the concentration of ligand when all of the binding sites are occupied The Ka is independent of such conditions as salt concentration and pH. The larger the Ka (association constant), the weaker the affinity. The larger the Ka, the faster is the binding. The larger the Ka, the smaller the Kd (dissociation constant). A. A. blood B. capillaries. in. B. D. red cells. E. the heart. During muscle contraction, hydrolysis of ATP results in a change in the: 71. C. D. E. conformation of actin. A. B. C. conformation of myosin. structure of the myofibrils. structure of the sarcoplasmic . reticulum. An allosteric interaction between a ligand and a protein is one in which: E. structure of the Z disk Single Proteins often have multiple subregions that show self-contained patterns of folding or function. These 72. binding of a molecule to a binding site affects binding of additional molecules to the same site. binding of a molecule to a binding site affects binding properties of another site on the protein. binding of the ligand to the protein is covalent. A. regions are called B. A. domains. B. oligomers. C. D. sites. E. subunits. C. multiple molecules of the same ligand can bind to the same binding site D. 73. In hemoglobin, the transition from T state to R state (low to high affinity) is triggered by: two different ligands can bind to the same binding site E. Which of the following is not correct oncerning cooperative binding of a ligand a protein? A. It is usually a form of allosteric A. Fe' bindin B. heme binding. C. oxygen binding. D. subunit association. E. subunit dissociation. interaction. B. It is usually associated with proteins with multiple subunits. C. It rarely occurs in enzymes. D. It results in a nonlinear Hill Plot E. It results in a sigmoidal binding curve