CHE 211 Final: Aerobic Respiration: Oxidative Phosphorylation
Organic Chemistry 2: Aerobic Respiration & Energy Production
Oxidative Phosphorylation
Once we have gone over the metabolic process of glycolysis, the oxidation of 2
molecules of pyruvate and citric acid cycle (2 molecules of Acetyl-CoA) this produces:
➢ From glycolysis: 2 molcules each of NADH and ATP
➢ From oxidation of pyruvate: 2 molecules of NADH
➢ From citric acid cycle: 6 molecules of NADH, 2 molecules of FADH2 and ATP
We will now see how the energy of electrons that are carried by NADH and FADH2
through the different biochemical pathways are converted to ATP energy; the series of
reactions is called oxidative phosphorylation (production of ATP using the energy of
electrons harvested during biological oxidation/reduction reactions)
Oxidative phosphorylation couples the oxidation of NADH and FADH2 to the
phosphorylation of ADP to generate ATP
The respiratory electron transport system is made up of a series of electron carriers
embedded in the inner mitochondrial membrane; electron transport system are series
of electron transport protein embedded in the inner mitochondrial membrane that
accepts high energy electrons from NADH and FADH2 and transfer them in a step wise
to molecular oxygen
At three sites in the electron transport system, protons, H+ can be pumped from the
matrix to the intermembrane space
- NADH provides three ATP molecules
- FADH2 provides two ATP molecules
ATP synthesis occurs at the ATP synthase
Electron Transport Systems
All of the molecules needed for this series of steps are located within the membrane of
the mitochondria in an arrangement that allows them to pass electrons from one to the
next (this array of electron carriers is called the respiratory electron transport system)
Embedded within the mitochondrial inner membrane are the electron transport
systems, electron carriers
- Coenzymes
- Cytochromes
- Arranged to allow them to pass electrons from one carrier to the next
This array is called the respiratory electron transport system
The Hydrogen Ion Gradient
At different three sites, protons, H +, can be pumped from the mitochondrial matrix to
the intermembrane space
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Document Summary
Organic chemistry 2: aerobic respiration & energy production. Once we have gone over the metabolic process of glycolysis, the oxidation of 2 molecules of pyruvate and citric acid cycle (2 molecules of acetyl-coa) this produces: From glycolysis: 2 molcules each of nadh and atp. From oxidation of pyruvate: 2 molecules of nadh. From citric acid cycle: 6 molecules of nadh, 2 molecules of fadh2 and atp. Oxidative phosphorylation couples the oxidation of nadh and fadh2 to the phosphorylation of adp to generate atp. At three sites in the electron transport system, protons, h+ can be pumped from the matrix to the intermembrane space. Atp synthesis occurs at the atp synthase. Embedded within the mitochondrial inner membrane are the electron transport systems, electron carriers. Arranged to allow them to pass electrons from one carrier to the next. This array is called the respiratory electron transport system.
