CHE 211 Study Guide - Final Guide: Oxidative Phosphorylation, Ketone, Phosphate
Organic Chemistry 2: Aerobic Respiration & Energy Production
Overview of Aerobic Respiration
Aerobic respiration is oxygen-requiring breakdown of food molecules and production of
ATP
Process also called oxidative phosphorylation that using high energy electrons that are
harvested from oxidation of substrates of the citric acid cycle to produce ATP; energy
from oxidative reactions is used to phosphorylate ADP making ATP
Performed by enzymes in the mitochondrial matrix
Three oxidations transfer hydride to NAD+ or FAD
Electrons passed from NAD+ or FAD to the electron transport chain and then O2
Protons are transferred to intermembrane space, leads to ATP synthesis as protons
return to mitochondrial matrix
The Citric Acid Cycle
Reactions – Citric Acid Cycle
• Lets take a look at the citric acid cycle
(Krebs cycle)
• Figure 22.5 from textbook
• The citric acid cycle is the final stage of
breakdown of dietary nutrients; acetyl-CoA
and oxoloacetate feed the citric acid cycle
• The Krebs cycle is a series of 8 reactions
that degrade acetyl-CoA to CO2 and energy
(lots of energy)
• We will follow the acetyl group as it makes
it way through the cycle
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Document Summary
Organic chemistry 2: aerobic respiration & energy production. Aerobic respiration is oxygen-requiring breakdown of food molecules and production of. Process also called oxidative phosphorylation that using high energy electrons that are harvested from oxidation of substrates of the citric acid cycle to produce atp; energy from oxidative reactions is used to phosphorylate adp making atp. Performed by enzymes in the mitochondrial matrix. Three oxidations transfer hydride to nad+ or fad. Electrons passed from nad+ or fad to the electron transport chain and then o2. Protons are transferred to intermembrane space, leads to atp synthesis as protons return to mitochondrial matrix. Citrate undergoes isomerization to produce iso-citrate; this isomerization actually occurs in 2 steps. In the first step which is catalyzed by aconitase, citrate undergoes dehydration reaction to form cis-aconitate. In the second step, the same enzyme catalyzes re-hydration of cis-aconitate to yield to.
