GENE 540 Midterm: p53 Tumor Suppressor
Document Summary
Families afflicted with li-fraumeni syndrome carry a germ- line p53 mutation and have a predisposition to early onset bone, brain, and lymphoid cancer. Cells from li-fraumeni patients are particularly sensitive to ionizing radiation. P53 is also involved in inherited mutations families with germ-line p53 mutation have a predisposition to early onset bone, brain and lymphoid cancer (li-fraumeni syndrome) The cells of li-fraumeni patients are particularly sensitive to ionizing radiation. P53 is a dna-binding transcription factor that is required for the dna-damage checkpoint. P53 is a dna-binding transcription factor required for the dna damage checkpoint. (it has other functions as well). P53 is not required for normal cell division or development (for the most part). P53 is a transcription factor that binds to dna and turns on the transcription of genes. One of the genes turned on is a cdk/cyclin inhibitor known as p21 leads to cell cycle arrest. Dna damage actually leads to stabilization of p53 on the.
