PHSC 4501 Study Guide - Midterm Guide: Cytochrome P450, Heteroatom, Medicinal Chemistry
1 Dec 2015
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Ion-dipole interaction: cation/anion +dipole, insensitive to temperature and distance. Induced dipole interactions: charge on one molecule induces a dipole on another, occurs between a quaternary ammonium ion and an aromatic ring. Polar regions of a drug and its target are solvated prior to interaction. The energy gained by drug-target interactions must be greater than the energy required for desolvation. The human body is ~75% water we use bronsted-lowery theory because drug is in dilute aqueous solution. Bronsted-lowery theory: acid: donates/loses a proton (h+) Converted to conjugate base: base: accepts/gains a proton (h+) To predict the solubility of a drug, one must weigh the number and strength of hydrophilic and lipophilic groups in a molecule. More significant induced dipole-induced dipole if 5-20 carbons. Chemical stability: chemically inert/stable in vitro (on the shelf) Metabolism: nonreactive will excrete from body unchanged, exceptions: Oxidation by enzyme cyp450 at the end of hydrocarbon or adjacent to the end hydrocarbon:
