NROSCI 0081 Study Guide - Midterm Guide: Mania, Bronchodilator, Gaba Receptor
29 Mar 2018
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What is a stimulant and what do they do? increase cns activity: what do we mean by sympathomimetic? sympathomimetic - increase the activity of the sympathetic nervous system increased hr, increased blood pressure, vasoconstriction, fight or flight. History of cocaine: natives in south america: chewed erythroxylon coca leaves, format: orally, concentration: low concentrations (0. 1-0. 9%) Isolated and purified form: originally used as local anesthetic, regulation and cocaine epidemic, 70"s 80"s, most popular in males age 12-39, often combined with alcohol. Produced cocaethylene (separate drug) in liver => creates dual dependency: enhances effect of cocaine, reduces drunk feelings, eases the come down from cocaine. Cocaine vs crack: freebase cocaine and crack can be heated => both can be smoked: crack gives you an instant high, unaltered cocaine powder cannot be smoked, crack cocaine gives you an instant high that is shorter. Powder cocaine-hcl inhaled sharply through nose: administration peak 15-20 min, distribution in brain 2-5 min inhalation.
