BIOL 53700- Final Exam Guide - Comprehensive Notes for the exam ( 78 pages long!)
29 Mar 2018
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Document Summary
The immune system is very important and is involved in infections, vaccines, cancer, transfusions/transplantations, autoimmunity, and allergy. Difficult because everyone"s bodies are different and this means so will there therapy and treatment of disease. Immunology- study of the body"s defense against infection. Roles of immune system: maintain homeostatic tissue functions, fight pathogens, repair tissue injury, tolerate commensal microbiome. Pathogen- an organism that can induce a pathology (disease) Van leeuwenhoek is the father of microbiology. What is the purpose of positive selection: what cells and molecules mediate positive selection, t cell negative selection. Slowly recovered: how do superantigens induce systemic shock, how do you determine whether a protein behaves as a superantigen, why is tsst-1 rare, mhc class 1 deficiency. How are tissue specific antigens present in the thymus for negative selection: hemolytic anemia, wilskott-aldrich syndrome. Lecture 7: t cell receptor and antigen presentation to t cells: t cell receptor structure, generation of tcr diversity, structure of mhc complex.
