14:440:301 Study Guide - Final Guide: Nuclear Receptor, Asteroid Family, Antimalarial Medication
30 Oct 2014
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Iba exam 3 lecture 1-2 (about 25 minutes into recording) 7 transmembrane gpcr, 7 sequences hooking back and forth through the membrane. Relaxation of smooth muscles, smooth muscles of the vascular tissues or bronchii tissues. Allow sufficient air to get into lung. Theres 4 notable mutations/polymorphisms and we"ll look at the amino acid correlation and the mutation that results in the amino acid substitution. These are all nonsynonymous mutations because they result in amino acid changes. Mutation at amino acid 27 where glutamate substitutes for glutamine the most resistant to drug-induced tolerance tolerance occurs the least in people with this kind of b- adrenergic receptors. Downregulation is in almost all cases is brought about by agonists protective mechanism to downregulate the receptor and dampen the response of the agonist. Very readily tolerant this variant here only about 30% loss in receptors these will benefit the longest in terms of duration when they are using b2-adrenergic receptors for asthma.
