14:440:301 Study Guide - Final Guide: Glucuronidation, Cytochrome P450, Metabolic Pathway

• School: Rutgers University
• Department: General Engineering
• Course: 14:440:301
• Professor: All

Document Summary

Notes from the 23rd, continue polymorphism lecture. When you see arrows in the notes pay attention to the sizes the contributions of particular pathways. In the case of codeine o-demethylation of codeine which is catalyzed by p450 2d6 not inducible, genetically polymorphic contributes only 2-5% of hepatic p450 but contributes to about 20% metabolism of all drugs. Glucuronidation at the 6th position is an activation, not a detoxification. Most of these reactions occur in the liver very important how morphine glucuronide gets from the liver into the brain one of the factors you need to consider is that cyp 2d6 and ugt. 2b7 are highly localized in certain neurons in the brain. Also need to remember that there are some transporters in the csf -bbb interface that acts as. Major detoxification enzyme -> plays critical role in the detoxification of many chemicals. Certain bioactivation reactions catalyzed by gst remember what class of chemicals are activated by gst .