01:119:115 Study Guide - Enzyme, Activation Energy, Covalent Bond
30 Oct 2014
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Catalyst: doesn"t alter free energy change of a reaction. Enzyme = biological catalyst: increases rate of biochemical reaction, can be used over and over, brings reacting materials together in correct configuration, lowers the free energy/activation energy needed. Enzyme substrate complex: substrate binds to enzyme"s active site, changes shapes of enzyme and substrate, induced fit helps break and form bonds. Most enzyme reactions are reversible; under equilibrium conditions: substrate product, a system at equilibrium cannot do work. Biochemical pathway: a b c d e (enzymes, change concentrations of reactants or products, to keep reaction to the right. Take away more e: to reverse reaction. Effect of temp increase of 10 degrees c will double the rate of the reaction. Bonds most sensitive to ph = ionic bonds, h bonds. When the inhibitor binds to the active site slows rate of reaction reversible. Inhibitor binds to another site of the enzyme and changes conformation. Inorganic cofactors (metal ions b/c of their charge)
