30:718:409 Midterm: COMAntianginal Spec Info

• School: Rutgers University
• Department: Pharmacology and Toxicology
• Course: 30:718:409
• Professor: Dr. Lavoie and Dr. Chakalamanil

Document Summary

Anti anginal: b-blockers, organonitrates, and ca2+ channel blockers. B-adrenergic blockers: non selective, propranolol, nadolol, b1 selective, atenolol, metoprolol, bisoprolol, nebivolol, beta-blockers with intrinsic sympathomimetic activity (partial agonistic activity, acebutolol. Organic nitrates and nitrites: amyl nitrate, structure, nitrite ester (r-o-n=o, roa. Inhalation only: not given orally due to poor oral absorption and extensive first pass hepatic metabolism. Indication: for the use of angina not for acute attacks, isosorbide dinitrate, structure, nitrate ester (o-no2, roa, sublingual, oral tablet, er tablet. 6 hours advantage: moa: does not inhibit pde6 (1) does not cause vision abnormalities, other: (1) shorter doa might decrease side effects (2) use 15 minutes prior to sexual activity, inhibits the (if) (na/k) pacemaker channel. Reduction of heart workload: roa: oral, side effects (1) bradycardia (2) atrial fibrillation (3) htn (4) luminous phenomena. Calcium antagonists aka calcium channel blockers: nifedipine. Indication: htn but also prescribed for angina, roa, only er less chance of reflex tachycardia, isradipine.