01:830:272 Final: DHB 830:360 opioids
28 Mar 2018
School
Department
Course
Professor
Document Summary
Contains morphine and codeine as natural products. Receptors exist because we have our own opiate like substances in brain and opiates attach to them too. Opioid terminology opioid: any antagonist with morphine-like activity narcotic: from narcos, any sleep-induing drug opium: exudate of the gum/milk from opium poppy plant opiate: drug (morphine, codeine) derived from opium poppy. 4 naturally occurring alkaloids (plant derived amines) that can be isolated from the poppy plant: Opium comes from the poppy plant, palaver somniferum (poppy that brings sleep) Not the same variety as the garden plant. Difficult to synthesize in the lab; most morphine still comes from the poppy plant. Naturally occurring opioids (2 main sources: opium poppy: morphine and codeine, vertebrate (& invertebrate) organisms: endogenous (made within) peptides with morphine- like actions. All other opioids are either semisynthetic or totally synthetic (made in lab) Pharmacologically, it makes no difference to the receptor. Schedule 1- no medical use, no benefit to society.
