PHR 4111- Final Exam Guide - Comprehensive Notes for the exam ( 38 pages long!)

• School: St. John's University
• Department: PHR - PHARMACY - PHARMD
• Course: PHR 4111
• Professor: Zito, Barletta, Ceterra

Document Summary

Block adh, aldosterone (which interferes with e and ne) e and ne release. All actions of natriuretic hormone effects lowering blood volume, keeping it down, blocking mechanism. Twins will have same interna function aka concordance in physiologic parameters suggesting that whatever is occuring in that indiv is genetically related. Strong suggestion familally that there is a genetic component. Higher than normal incidence of htn in twins. Gwas is why it"s so hard to find single bp problem. Ras is dysfunctional not because system itself is defective but because it is being stimulated by defectory genes. Cortisol, aldosterone and other hormones have steroid backbone (similar comp) Cortisol build up is enough to cause activation of ras. Normally sodium channels in kidney require stimulation for activation/complete activation. In this case na channels are always working. Refers to formation within vascular lumen of thrombus defined as an aggregate of coagulated blood containing platelets, fibrin, entrapped cellular elements.