Study Guides (248,397)
United States (123,373)
Biology (91)
BIOL 1911 (10)

Ch 43 Articles Study Guide.doc

4 Pages
Unlock Document

BIOL 1911
Eileen Wood

Ch 43 Articles Study Guide Love with the Proper Stranger Why are people attracted to particular members of the opposite sex? We are members of a sexually reproducing species and need to join up with someone of the opposite sex to mate, conceive offspring, and pass our genes onto the next generation Who are the Hutterites? Hutterites are people who can trace their ancestry back to the 400 members of the Anabaptist sect who migrated from Europe to the US who settled in South Dakota. According to geneticists, they are ideal subjects because the 400 original settlers were closely related and believed to be descended from 90 individuals. And they are usually inbred because they must marry inside their own group. What are the various alleles for HLA and how many exist per? Why are there so many? Various alleles referred by letters A, B, C, DR, DQ, DP, E, F, and G. There are at least 60 of the A gene, 150 of the B, 180 of the DR, and so on. At least 80 million combinations are possible. There are a lot of combinations because the HLA system tells the body to reject tissue that does not match its own. What is the relationship between HLAs and pregnancy? There is a higher risk for miscarriage when a man and woman with similar HLA haplotypes conceive. Natural selection favors fetuses with HLA genes different from their mothers’. How did researchers demonstrate that exposure during development (not mate MHC type) drove mate choice? When the time came for males to choose mates, they avoided females whose MHC genes were similar to their foster mothers’, even when that meant winding up in the position of mating with a female whose MHC genes were similar to their own. How might people “imprint”? How did researchers test the scent hypothesis with people? How contraceptives influence the findings? Pregnancy Reconceived What is the immunological paradox of pregnancy? The fetus is like a semiforeign transplant, because half of its genes come from the father. Therefore the mother’s immune system and the fetus must be locked in conflict. What are the hypotheses that explain a mother’s tolerance of an embryo? How does the author refute each? • The trophoblast forms some kind of mechanical barrier. Studies indicate the placenta is not as impermeable as originally envisioned. • The mother’s immune system is suppressed during pregnancy. If pregnant women were immunologically suppressed, they would’ve died within hours of exposure to pathogens. HIV is less likely to develop into AIDS during pregnancy. • The mother’s immune system is suppressed, but only locally, in the vicinity of the trophoblast. Removing macrophages that would be expected to attack the trophoblast cause pregnant mice to miscarry. • The balance of cytokines shifts during pregnancy. Pregnancy can be either a pro- or anti-inflammatory condition based on the stage. First and third trimester inflammation occurs, while in the second it doesn’t. What is FasL? A protein secreted by trophoblast cells that are said to bind to Fas cells and induce apoptosis. What is the anti-inflammatory theory of pregnancy? Cytokine-shift theory? Cytokine-shift theory (aka the anti-inflammatory theory of pregnancy): pregnancy changes the balance of cytokines, suppressing the inflammatory response and creating an anti-inflammatory environment. Why were findings from testing these hypotheses contradictory? Some studies found a shift toward anti-inflammatory cytokines in the mother’s blood while others didn’t. How are trophoblast cells and macrophages similar? They both have signal receivers called Toll-like receptors (TLRs) on their cell membranes that enable trop
More Less

Related notes for BIOL 1911

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.