NSCI 1051 Study Guide - Midterm Guide: Nicotinic Acetylcholine Receptor, Nicotine, Reversal Potential
24 Oct 2016
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If a alone fires, more likely to fire. If b alone fires, less likely to fire. *outside-out method is a patch clamp method. The portion that faces extracellular face is facing out. Important when studying ligand gated channels because otherwise ligand cannot bind. Any ion species that does not movie thru ion channel. If you lower this, you are shifting it more negative because now top part of nernst equation will be more similar to bottom giving you a less positive na+ potential. *the fact that you can change the ion concentrations means they must flow through and both must be permeable to ion channel. Voltage clamping a muscle holds muscle steady and measures current. Each individual ion species has its own equilibrium potential. Lower external na+ shifts reversal potential to the left. Higher external k+ shifts reversal potential to the right. With temporal summation, the closer together the synapses, the more likely to fire.
