BSC 431 Study Guide - Midterm Guide: Pneumocystis Jirovecii, Chlamydophila Psittaci, Zygomycosis

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 431
• Professor: Julie Olson

Document Summary

Found in soil, water, sewage (decaying vegetable matter) People in contact w/ domestic animals my be asymptomatic carriers. Refrigerated soft cheeses, deli meats, hot dogs, milk, raw vegetables. Late onset- acquired at or soon after birth. Cells colonize in intestine & invade lymphoid tissue. Survives phagocytosis & moves throughout body w/in maceophage. Listerolysin o- disrupts the endosome membranes and releases the bacteria into the cytosol. Phospholipase c enzymes- help release bacteria into cytosol. Seen on fingers/hands from direct contact w/ infected meat. Lam (libroarabinomannan) binds to mannose receptors on macrophages. Infected macrophages spread to lymph nodes: t cells infiltrate, stimulate release of cytokines, cytokines activate macrophages, tubercles form. Caseous center of tubercles can liquefy, which allows bacteria to replicate extracellularly. Tubercle can invade blood vessels & other parts of lungs. For active tb: microscopy, culture, x-ray, pcr (rapid but expensive) Must be given for 6-9 months in combination. Lumps & thickenings, blindness, nasal cartilage destroyed, loss of sensation in extremities.