BIL 255 Study Guide - Comprehensive Final Guide: Hbb, Gene Duplication, Horizontal Gene Transfer

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29 Nov 2016
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Specific condon in mrna signal the ribosome where to start and stop protein synthesis: A specific signal required o initiate translation is crucial, because it sets the reading frame for the whole length of the message. An error of one nucleotide either way can cause damage to the protein. Translation begins with the codon aug and a special trna is required to initiate translation. Initiator trna: always carries the amino acid methionine (met). Therefore all newly made proteins have a methionine as the first amino acid at their n-terminal end, the end that is usually synthesized 1st. Note: the 2nd amino acid will come and bind on the a-site. Transitional initiation factors: protein that promotes the proper association of ribosomes with mrna and is required for the intiation of the protein. Initiation of protein synthesis in euk requires translation initiation factors and a special initiation trna. The mrna is scanned for the first aug.

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