MICROM 442 Study Guide - Final Guide: Heat Shock Protein, Shigella, Fibronectin
Document Summary
Common bacterial pathogens, but only recently discovered (last 50 years) Microaerophilic (prefer 5-10% oxygen vs. 20% in air) Infect gi tract of humans (and other animals) C. fetus isolated from aborted sheep in 1909, genus described in 1963, campylobacter isolated from human diarrheal stool in 1972. Cause of the majority of foodborne bacterial infections in developed nations. Symptoms: diarrhea (sometimes bloody dysentery), fever, abdominal pain, inflammation. In severe cases (including bacteremia, immunocompromised patients, patients with bloody stools), antibiotics should be given. Serum serology and pcr tests exist, but are currently only used for research. Flagellin (flaa, flab) expression can be turned off by slip-strand mispairing (phase variation) Flagellin glycosylation is important for autoaglglutination, microcolony formation. Attracted primarily to the mucins and glycoproteins of musuc, but also to nutrients. Capsule: is important for survival, adherence, immune evasion. >100 serotypes, very high diversity of core oligosaccharides. Activates atm, p53 causing cell type specific arrest/apoptosis.
