CHEM 153C Quiz: Problem set 1 questions
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Study questions and problems i: compare a reaction selected from the -oxidation cycle of fatty acid oxidation or the biosynthesis of acetoacetate with a closely analogous reaction of the tricarboxylic acid cycle. Select reactions for comparison in which the chemical changes involved and the mechanistic features bear a close resemblance to one another. Illustrate the reactions and comment on the most important features they have in common: illustrate with structural formulas one reaction of physiological importance for each of the following cases. Coenzymes may be abbreviated in standard fashion; intermediates and mechanisms need not be indicated. Ch: show the structure of 3-hydroxy-3-methylglutarylcoa and indicate clearly with an asterisk the labeling pattern expected in this substance when it is produced in liver mitochondria that are carrying out the oxidation of 2-[14c]-palmitoylcoa. (ch2)10. Ch2 cscoa: the cleavage of acetoacetylcoa to 2 acetylcoa catalyzed by the enzyme 3-ketothiolase is thermodynamically favorable under standard state conditions ( go = -6. 7 kcal mol-1).
