LIFESCI 3 Final: LIFESCI 3, Final Part 1
Document Summary
Transcription occurs in 5" to 3" direction. Has cycles of initiation, elongation, and termination. At least 3 different rna polymerases (rnap i transcribes only one gene of pre-rrna, but it is huge (remember, rrna makes up 80% of the rna in the cell)) Each rnap has a similar structure to bacterial rnap. Basically the same function, so very similar structure. Homology between the seq for each different rnap. Each has homologous subunits to the 5 subunits of rnap in bacteria (beta, beta", alpha, alpha", omega) Peripheral of the rnap is different (where the more subunits are) Eukaryotes require much more regulation in transcription, and thus have to be able to interact/communicate with many other proteins (need a larger surface area with more subunits) Initiation factors are needed to get rnap ii to the promoter, recognize the seq, and get initiation started.
