MIMG 101 Study Guide - Final Guide: Reverse Transcriptase, Ribonuclease H, Rna-Dependent Rna Polymerase

• School: UCLA
• Department: Microbiology, Immunology, and Molecular Genetics
• Course: MIMG 101
• Professor: G U N S A L U S& B R A D L E Y

Document Summary

Dna in bacteriophage not fully intact, thus not infective. Synthesis of bacteriophage materials in permissive host. Salk"s ipv: treat and fix with formaldehyde, normal, dead vaccine. Co infection of diff strains in same organism -> reassortment -> pandemic. Phi x174 (circular ss + dna: rf, rolling circle, a/e proteins, a nicks and ligates, e lyses by blocking peptidoglycan synthesis. Ms 2 (ss + rna: stem loop regulation, coat, lysis, replicase. Polio: polyprotein, vpg protein (prime strand for synthesis, polyprotein proteases, coat, replicase, protease degrades host cap binding proteins -> host only synthesize things w/ Flu: cap snatching, brings own replicase. Interferes with host transcription, modifies host mrna -> disease. Aerial tubes: differentiation, stationary phase, antibiotics production. Spores stationary phase, tip conformation changes. Vegetative feed thru exoenzymes, a/s motility, growth phase. Mounds part of vegetative, not growth phase though. Fruiting bodies stationary phase, diff cell fates. Adventurous: patrol and relay info, use adhesion and gliding.