AH 3121 Study Guide - Midterm Guide: Interleukin 4, Phagocytosis, Interleukin 3
Document Summary
When integrins of effector t cells encounter their ligands on vessel endothelial cells, t cells bind to endothelium and migrate to infected tissue site. The chemokines produced by macrophages at infection site attract white blood cells and stimulate motility. The 4 steps of lymphocyte extravasation are primary adhesion to endhothelium, lymphocyte activation, secondary adhesion (arrest), and transmigration/chemotaxis. The three types of effector t cells are cytotoxic t cells, th1 cells, and th2 cells. The effector molecules involved with cytotoxic t cells are: perforin, granzymes, granulysin, fas ligand. The non-effector molecules involved with cytotoxic t cells are: ifn-gamma, tnf-beta, tnf-alpha. The effector molecules associated with th1 cells are: ifn-y, gm-csf, tnf-a, cd40 ligand, fas ligand. The non-effector molecules involved with th1 cells are: il-3, tnf-b, il-2. The effector molecules associated with th2 cells are: il-4, il-5, il-15, cd40 ligand. The non-effector molecules associated with th2 cells are: il-3, gm-csf, il-10, tgf-b, eotaxin. You would associate th1 cells with intra-vesicular bacteria.
