PNB 2265- Final Exam Guide - Comprehensive Notes for the exam ( 243 pages long!)
1 Dec 2017
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Sickle cell disease: a single point mutation in the beta chain results in misfolding of the beta chains, the effect varies in severity depending upon expression level and the specific mutation. Iron deficiency: 4 heme groups=4 irons, if you have no iron, you can"t make more protein. Blood doping: artificial polycythemia, infusion of packed rbc, erythropoietin supplement. Implicated in numerous deaths: lance armstrong could never be caught because the tests couldn"t detect his polycythemia, hematocrit increases, so you drink a lot of water or iv saline. Normal rbc catabolism: red blood cells survive for approximately three months inside the body before undergoing apoptosis, very controlled manner, cell that contains hemoglobin. Main part of hemoglobin is iron: phagocytosis by macrophages, take cell in and break it down, protein components, heme is converted to biliverdin, then bilirubin. Iron (fe) component: very reactive, transported by transferrin to bone marrow. To travels safely through the bloodstream: stored in cells by ferritin.
