PNB 2265 Study Guide - Final Guide: Simple Columnar Epithelium, Carbonic Anhydrase, Gastric Glands
10 Oct 2018
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The cumulative final exam (exam 4) covers material from all three exams. Rather, we are providing objectives for the material from the (cid:862)old(cid:863) exams, to help you organize that material. Is produced by parietal cells (also called oxyntic cells) in the gastric glands in the stomach. This creates carbonic acid which disscociates into hco3- and h+. Hco3- is then transported on basolateral membrane in exchange for cl- which is secreted out the apical membrane using cftr transporter. H+ secreted out apical membrane through h/k atpase (proton pump) brings k+ into the parietal cell. Histamine released by mast cells (enterochromaffin) increase camp and activate pka which phosphorylates the proton pump. Binding ach and gastrin (g-cells) both result in elevation of intracellular calcium concentrations. Activated by kinases in the duodenum into trypsin which breaks down proteins at aa: chymotrypsinogen, releases in pancreas, activated in duodenum into trypsin which breaks down proteins at aa, hcl.
