MCDB 153 Study Guide - Final Guide: Apoptosis, Sox2, Filopodia
Document Summary
Take blastocoel from early gastrula and translate it to another host-> the animal ends up with 2 neural systems. Shows that epithelial cell has signaling factors introduced the concept of induction in embryonic development. Epidermal cell induce neighboring cells to change their fate demonstrated the existence of an organizer that instructs both neuralization and dorsalization, and showed that cells can adopt their developmental fate according to their position when instructed by other cells. Neural is the default fate for ectodermal cells; Expt: dissociation of animal cap cells prior to gastrulation causes them to differentiate into neurons in culture. Under normal circumstances, bmp4 induces ectodermal cells to become epidermal; Noggin, chordin and follastatin from the mesoderm all interfere with. Bmp-4 signalling in the regions to become neural. Expt: bmp 4 can cause dissociated cells that would have become neural to instead become epidermal. Bmp-4 binds to noggin, which binds to tfgb- receptor.