NSCI320- Midterm Exam Guide - Comprehensive Notes for the exam ( 139 pages long!)
5 Oct 2017
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Vs ramachandran: 3 clues to understanding your brain. Michael merzenich: growing evidence of brain plasticity: brain is all about change born stupid. Infant low cognitive ability: not much response, several months before voluntary control motion, growing cognitive skills. Immunocytochemistry localize molecules to cell produce antibodies labelled w/ markers for identification recognizes antigen (neurotransmitter/receptor: anti-oxytocin ab. In situ hybridiztation: localize synthesis of protein/peptide to a cell, detect mrna, studying release, transmitter candidate, cns contains diverse mixture of synapses uses different neurotransmitters, brain slice as a model. Identify natural receptors using radioactive ligands: can be: agonist, antagonist, chemical neurotransmitter, molecular analysis receptor protein classes, transmitter-gated ion channels, gaba receptors, 5 subunits, each made with 6 different subunit polypeptides, g-protein coupled receptors. Indolamines (serotonin: cell bodies = in brainstem give rise to axon terminals = distributed widely throughout the brain, catecholaminergic neurons, movement, mood, attention, visceral function, tyrosine (synth in body (phenylalanine, precursor for three amine neurotransmitters.
